Phospholipase C-β in immune cells
نویسندگان
چکیده
منابع مشابه
Phospholipase C in Living Cells
We have further tested the hypothesis that receptor-mediated modulation of KCNQ channels involves depletion of phosphatidylinositol 4,5-bisphosphate (PIP2) by phosphoinositide-specific phospholipase C (PLC). We used four parallel assays to characterize the agonist-induced PLC response of cells (tsA or CHO cells) expressing M1 muscarinic receptors: translocation of two fluorescent probes for mem...
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Phospholipase C (PLC) enzymes convert phosphatidylinositol-4,5-bisphosphate into the second messengers diacylglycerol and inositol-1,4,5-triphosphate. The production of these molecules promotes the release of intracellular calcium and activation of protein kinase C, which results in profound cellular changes. The PLCβ subfamily is of particular interest given its prominent role in cardiovascula...
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The presence of the pertussis toxin (PTX) insensitive GTP-binding proteins (C-proteins) G(q) alpha and/or G(11) alpha has been demonstrated in three different prolactin (PRL) and growth hormone (GH) producing pituitary adenoma cell lines. Immunoblocking of their coupling to hormone receptors indicates that G(q) and/or G(11) confer throliberin (TRH) responsive phospholipase C (PL-C) activity in ...
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Introduction One early transmembrane signal in response to stimulation of the T-cell antigen receptor (CD 3/Ti) is the activation of phosphatidylinositol (Ptd1ns)specific phospholipase C (PLC). The resulting formation of inositol 1,4,5-trisphosphate (Ins( 1,4,5)q?) and diacylglycerol (DAG) causes calcium release from internal stores, calcium influx through calcium channels, and translocation of...
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Elucidation of the mechanisms responsible for aberrant phosphatidylcholine (PC) metabolism in cancer cells may allow identification of novel biomarkers of tumor progression and design of new targeted anticancer therapies. We recently reported up-regulation of PC-specific phospholipases in epithelial ovarian cancer cells (EOC) compared with nontumoral (normal or immortalized) counterparts (EONT)...
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ژورنال
عنوان ژورنال: Advances in Biological Regulation
سال: 2013
ISSN: 2212-4926
DOI: 10.1016/j.jbior.2013.08.001